True love is a blessing and a curse.
She's the blessing. He's cursed.

It all started when Charlie Kagan was ten years old. Breaking the cardinal rules of spin the bottle, Charlie refused to lip lock with a demented Goth girl and she put a hex on him.

Now, twenty five years later, Charlie (Dane Cook) is a successful dentistand still cursed. While his plastic surgeon best friend, Stu (Dan Fogler), pursues as many of his patients as possible, Charlie can't seem to find the right girl. Even worse, he discovers at an ex-girlfriends wedding that every woman hes ever slept with has found true love with the next guy after him. Before he knows it, Charlie's reputation as a good luck charm has women from sexy strangers to his overweight receptionist lining up for a quickie. But a life filled with all sex and no love has Charlie lonelier than ever that is, until he meets Cam (Jessica Alba).

An accident prone penguin specialist, Cam is as hard to get as she is beautiful. But when a genuine romance develops, Charlie realises he's got to find a way to break his good luck curse before the girl of his dreams winds up with the next guy she meets.