Thunderbirds Are Go: Zero-X, a manned exploration mission crashes during lift-off on its maiden flight. Two years later an investigative committee finally concludes sabotage, and decides to call on the services of International Rescue to oversee security at the impending second launch. The second Zero-X successfully reaches its destination, but encounters unexpected hazards, ultimately leading to another call for assistance on its return to Earth. International Rescue respond, and once again Thunderbirds are GO!

Thunderbird 6: In the 21st century, Jeff Tracy, a former astronaut, amasses a colossal fortune and decides that he must use it to benefit others. His answer to this desire is to create International Rescue, a unique private emergency response service equipped with customed designed vehicles and equipment that enable the organization to react to any crisis whether it be in sea, air, land, or space. Jeffs sons volunteer to operate as the field agents as well as Harim "Brains" Hackenbaker as the team engineer. In addition, Jeffs friend, Kyrano and his niece Tin Tin agree to be the support staff. In addition to the field team, IR also maintains an intelligence network with Lady Penelope and her ex-con chauffer, Parker as the chief agents in this arm. The series depicts this team as they answer various calls for help around and beyond the world while they prevent enemies like the Hood from learning and exploiting their secrets.